Rosuvastatin and alcohol: What should you know?

Rosuvastatin is one of the most commonly prescribed statins used for the treatment of high cholesterol and the prevention of cardiovascular diseases. Statins, such as rosuvastatin, work by inhibiting cholesterol production in the liver, which helps lower blood LDL cholesterol levels. This medication is an effective way to reduce the risk of cardiovascular diseases, but there are certain considerations to keep in mind regarding its use, particularly concerning alcohol.

The use of alcohol with rosuvastatin is not directly prohibited, but it should be considered carefully. Both rosuvastatin and alcohol can affect the liver, so combining them may increase the risk of liver damage.

 Liver health: Rosuvastatin, like other statins, is primarily metabolized in the liver. Therefore, the risk of liver damage may increase if the liver is subjected to additional stress from alcohol consumption. Alcohol can cause liver damage, especially with long-term or excessive use, and this, in conjunction with rosuvastatin, may increase the risk of serious liver damage.

Liver-related side effects: Although rosuvastatin is generally well tolerated, it can elevate liver enzyme levels in some patients, which may indicate liver damage. Alcohol can exacerbate this condition and lead to more severe liver damage, such as hepatitis or fatty liver.

When rosuvastatin is used in conjunction with alcohol, certain side effects may become more likely or severe:

1. Liver damage: As mentioned, both rosuvastatin and alcohol can affect the liver. If a patient regularly consumes alcohol while taking rosuvastatin, the risk of liver damage significantly increases. This can lead to symptoms such as abdominal pain, jaundice (yellowing of the skin and eyes), and dark-colored urine
2. Muscle pain: Statins can cause muscle pain or weakness, and alcohol consumption may exacerbate this symptom.Especially large amounts of alcohol can increase the risk of serious muscle damage, rhabdomyolysis, which is a rare but serious condition where muscle tissue breaks down and releases dangerous proteins into the bloodstream, potentially leading to kidney damage.
3.  Fatigue and weakness: Alcohol can also amplify some of the milder side effects of rosuvastatin, such as fatigue and weakness. This can affect overall well-being and daily functioning.

Since alcohol can increase the side effects of rosuvastatin, it is advisable to exercise caution with alcohol consumption.Although there is no exact amount of alcohol that is considered "safe" when using rosuvastatin, experts generally recommend minimal or moderate alcohol consumption.

Moderate alcohol consumption: This generally means up to one drink per day for women and up to two drinks per day for men. One alcoholic drink is equivalent to about 12 cl of wine, 3.5 dl of beer, or 4 cl of spirits.

Individual consideration: Each body reacts differently to both rosuvastatin and alcohol. If you have had liver problems or are taking other medications that may affect the liver, it may be best to avoid alcohol altogether.

Since both rosuvastatin and alcohol can affect the liver, it is important to implement measures to protect the liver.

1. Limit alcohol consumption: As mentioned, limiting or avoiding alcohol consumption altogether is important to prevent additional strain on the liver.

1.  Healthy diet: A diet rich in vegetables, fruits, and fiber can help keep the liver healthy. Avoid foods high in saturated fats and sugars, as they can increase the risk of fatty liver.

2.  Regular monitoring: If you are using rosuvastatin, it is important to have regular blood tests to check liver health. This way, any potential issues can be detected early.

3.  Avoid other substances that burden your liver: For example, excessive use of certain pain relievers, such as paracetamol, can also strain the liver. Discuss with your doctor if you are using other medications or dietary supplements.